The hormones and endorphins released in the "play"
Affect men and women completely differently. This can be very dangerous.
Women have up to 30 different sections of the brain activated just prior to and at the time of orgasm.
The primary areas are responsible for emotion, touch, joy, satisfaction and memory. The woman's reward center in the brain activates as the excitement mounts. During normal sexual interaction that may be within two minutes of orgasm, but in Sensual Bondage and Power Exchange Play that could last for 45 minutes or more. As they edge to near peak their sensory cortex becomes super active. It handles messages from "touch" signals from the body. At the peak of excitement the woman's hypothalamus activates, it handles "control" of body temperature, hunger, thirst and how tired they feel.
Those who enjoy impact play such as spanking; it is critical to understand that at the height of sexual arousal a woman's body numbs itself the point that it deadens pain accentuating pleasure. Such numbness increases the risk of injury or over stepping of limits due to the skewed sensory inputs at that moment.
As a Training DOM I have seen cases where the sub will beg and demand to be spanked harder and harder or with other objects like whips and paddles until they are bleeding. Such a situation should never be allowed to occur. Thus is the reason for the absolute need for discussion about the way they think, how a skilled DOM can use that to their mutual benefit and how a caring, sane DOM will protect the sub by erring on the side of caution.
Women have one set of responses often overwhelmed by the "cuddle" hormone (yes it is real). Women can behave erratically (some might say crazy), possessive and even downright destructive if things don't go just slightly as they want.
Men only have one trigger in their physiology; pleasure via dopamine. Dopamine can be addictive which is why men are much more likely to have a sex addiction. Unfortunately, these fundamental scientific differences are why unless carefully managed, Men and Women end up in conflict and major confusion with how their partner responds and behave after the encounter.
This is why lots of detailed conversation is necessary prior to and after play. This game has rewards not possible in a vanilla world but requires above average self control, intellect and care to gain the spoils of the play.
It is also important to note that such chemical and neurological responses make the submissive (if a female) more at risk to approve high risk or unhealthy activities; whether it is unsafe sex with partners unknown or multiple or begging to be whipped instead of spanked or flogged. Such subtle differences "in the heat of the moment" could result in STDs, pregnacies, immediate lasting injuries or worse.
Please, if you are planning on adding some kink to you sex life, PLEASE be responsible and safe. Educate yourself and make sure that you totally know and trust your partner. Trust alone is not enough to keep you safe. You must understand the boundaries of science, safety, health and your physical condition.